Alexis Brice Selected Research

autosomal dominant Spastic paraplegia 3

9/2009	Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulum.
12/2004	Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A.

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Alexis Brice Research Topics

Disease

72	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2002
32	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2022 - 01/2002
18	Parkinsonian Disorders (Parkinsonism) 01/2018 - 04/2002
15	Frontotemporal Dementia (Semantic Dementia) 12/2021 - 07/2002
14	Cerebellar Ataxia (Dysmetria) 01/2022 - 07/2002
14	Hereditary Spastic Paraplegia 01/2018 - 05/2002
12	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 07/2002
12	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2021 - 07/2004
11	Alzheimer Disease (Alzheimer's Disease) 09/2019 - 08/2002
11	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 02/2016 - 07/2008
10	Ataxia (Dyssynergia) 01/2022 - 02/2006
10	Dementia (Dementias) 10/2020 - 08/2003
9	Cognitive Dysfunction 01/2021 - 08/2003
9	Atrophy 01/2021 - 07/2003
6	Disease Progression 01/2020 - 01/2016
6	Tremor (Tremors) 04/2013 - 06/2007
5	Paraplegia (Spastic Paraplegia) 12/2018 - 12/2004
5	Huntington Disease (Huntington's Disease) 06/2016 - 02/2002
4	Disruptive, Impulse Control, and Conduct Disorders (Kleptomania) 01/2020 - 10/2016
4	Movement Disorders (Movement Disorder) 10/2013 - 08/2003
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 03/2006
3	Dyskinesias (Dyskinesia) 01/2021 - 01/2011
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 05/2008
3	Neoplasms (Cancer) 03/2017 - 05/2013
3	Gaucher Disease (Gaucher's Disease) 11/2016 - 01/2011
3	Epilepsy (Aura) 12/2014 - 04/2004
3	Dopa-responsive Dystonia 09/2014 - 08/2003
3	Dystonia (Limb Dystonia) 09/2014 - 08/2003
2	Inflammation (Inflammations) 10/2020 - 12/2014
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2020 - 12/2014
2	Lewy Body Disease (Lewy Body Dementia) 01/2020 - 06/2013
2	Osteitis Deformans (Paget's Disease of Bone) 12/2018 - 01/2015
2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 12/2017 - 12/2014
2	Channelopathies 06/2017 - 11/2015
2	Nervous System Diseases (Neurological Disorders) 03/2017 - 01/2017
2	Pallidopyramidal syndrome 07/2015 - 04/2013
2	Friedreich Ataxia (Friedreich's Ataxia) 06/2015 - 12/2003
2	Peripheral Nervous System Diseases (PNS Diseases) 02/2015 - 10/2011
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 09/2014 - 08/2012
2	Hypokinesia (Bradykinesia) 01/2011 - 12/2009
2	autosomal dominant Spastic paraplegia 3 09/2009 - 12/2004
2	Intellectual Disability (Idiocy) 07/2009 - 01/2008
2	Oculomotor Nerve Diseases (Oculomotor Nerve Palsy) 03/2004 - 12/2003

Drug/Important Bio-Agent (IBA)

33	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2002
22	polyglutamineIBA 01/2018 - 01/2002
17	Phosphotransferases (Kinase)IBA 01/2019 - 03/2006
16	Leucine (L-Leucine)FDA Link 01/2019 - 09/2006
13	Biological ProductsIBA 01/2022 - 12/2003
12	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 04/2002
12	UbiquitinIBA 01/2016 - 01/2002
11	Biomarkers (Surrogate Marker)IBA 12/2021 - 10/2012
11	ProgranulinsIBA 01/2021 - 04/2007
11	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 06/2003
8	Ataxin-7IBA 11/2019 - 06/2002
8	alpha-SynucleinIBA 01/2018 - 01/2002
7	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 07/2009
6	Glucosylceramidase (Glucocerebrosidase)IBA 01/2020 - 01/2011
6	SynucleinsIBA 01/2019 - 10/2011
5	EnzymesIBA 01/2020 - 05/2003
5	SpastinIBA 12/2018 - 08/2003
5	tributyl phosphate (TBP)IBA 01/2018 - 07/2003
5	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2006 - 01/2002
4	Amyloid (Amyloid Fibrils)IBA 01/2021 - 05/2003
3	Apolipoproteins E (ApoE)IBA 12/2019 - 07/2002
3	LipidsIBA 09/2019 - 09/2009
3	Dihydroxyphenylalanine (Dopa)IBA 02/2016 - 08/2003
3	Messenger RNA (mRNA)IBA 01/2016 - 02/2002
3	CalciumIBA 11/2015 - 04/2005
3	DNA (Deoxyribonucleic Acid)IBA 05/2015 - 06/2005
3	Ligases (Synthetase)IBA 11/2009 - 01/2002
3	protein kinase C gamma (PRKCG)IBA 06/2007 - 08/2004
3	ApolipoproteinsIBA 07/2005 - 07/2002
2	Dopamine Agonists (Dopamine Agonist)IBA 01/2020 - 12/2018
2	Opioid Receptors (Opioid Receptor)IBA 01/2019 - 12/2018
2	Carrier Proteins (Binding Protein)IBA 01/2019 - 05/2013
2	indium arsenide (InAs)IBA 09/2018 - 11/2015
2	GangliosidesIBA 01/2018 - 07/2013
2	phosphomannomutaseIBA 12/2017 - 12/2014
2	Congenital disorder of glycosylation type 1AIBA 12/2017 - 12/2014
2	IronIBA 07/2015 - 07/2002
2	FrataxinIBA 06/2015 - 07/2002
2	NucleotidesIBA 02/2015 - 11/2010
2	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2014 - 04/2009
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 09/2014 - 08/2003
2	Guanosine Triphosphate (GTP)IBA 09/2014 - 07/2009
2	preproenkephalinIBA 07/2013 - 03/2002
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 08/2012 - 04/2009
2	sepiapterin reductaseIBA 11/2011 - 07/2009
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/2011 - 03/2002
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 07/2009 - 03/2002
2	CholesterolIBA 05/2008 - 02/2005
2	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2008 - 07/2003
1	Riluzole FDA LinkGeneric 01/2022
1	Mitochondrial RNAIBA 01/2022
1	PolymersIBA 01/2022
1	Coffee FDA Link 01/2022

Therapy/Procedure

9	Therapeutics 12/2021 - 02/2011
2	Deep Brain Stimulation 01/2020 - 02/2016
2	Denervation 05/2015 - 09/2014
2	Ligation 05/2014 - 10/2012